Electroretinography Changes in Feline Model of Iodoacetic Acid-induced Retinal Degeneration
نویسندگان
چکیده
منابع مشابه
Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration.
PURPOSE. Transgenic pigs carrying a mutant human rhodopsin transgene have been developed as a large animal model of retinitis pigmentosa (RP). This model displays some key features of human RP, but the time course of disease progression makes this model costly, time consuming, and difficult to study because of the size of the animals at end-stage disease. Here, the authors evaluate an iodoaceti...
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In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death providing a tractable model of retinal degeneration in these species. This study investigated the long term effects of photoreceptor loss in an ATP induced feline model of retinal degeneration. Six normal sighted felines were unilaterally blinded using intravitreal AT...
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Seven domestic cats with feline central retinal degeneration (FCRD) were investigated by ophthalmoscopy, fluorescein angiography, electroretinography, and light and electron microscopy. Little or no increase in lesion size was observed ophthalmoscopically over periods as long as four years. Five cats showed normal rod electroretinographic (ERG) responses and abnormal cone responses. In one cat ...
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ژورنال
عنوان ژورنال: Journal of the Korean Ophthalmological Society
سال: 2019
ISSN: 0378-6471,2092-9374
DOI: 10.3341/jkos.2019.60.12.1205